vismodegib

English

Etymology

Formed with -degib.

Noun

vismodegib (uncountable)

1. (pharmacology) A drug targeting the smoothened protein of the hedgehog signaling pathway, used for the treatment of basal cell carcinoma.
   • 2016 March 3, “Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells”, in PLOS ONE‎^[1], →DOI:

     Among the inhibitors of the Hh pathway that interact directly with SMO, vismodegib and sonidegib are the two compounds approved by FDA in 2012 and 2015, respectively, for the treatment of basal cell carcinoma (BCC).