smoothened
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English
[edit]Etymology 1
[edit]Verb
[edit]smoothened
- simple past and past participle of smoothen
Etymology 2
[edit]
Ultimately the same as etymology 1. The gene encoding the protein was first identified in Drosophila melanogaster as a segment polarity gene and initially named smooth (smo) by Christiane Nüsslein-Volhard et al. in 1984.[1] This was later revised to smoothened by Dan L. Lindsley and Georgianna G. Zimm in 1992,[2] because the former name already described another locus.[3]
Alternative forms
[edit]Noun
[edit]smoothened (uncountable)
- (biochemistry) A transmembrane protein belonging to the group of G protein-coupled receptors that is a key component of the hedgehog signaling pathway.
- Synonym: (abbreviation) Smo
See also
[edit]References
[edit]- ^ Christiane Nüsslein-Volhard, Eric F. Wieschaus, H. Kluding (1984 September) “Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster: I. Zygotic loci on the second chromosome”, in Roux's Archives of Developmental Biology, volume 193, Springer-Verlag, , page 274
- ^ Dan L. Lindsley, Georgianna G. Zimm (1992) “Genes”, in The Genome of Drosophila melanogaster, San Diego, Calif.: Academic Press, Inc., , →ISBN, page 649
- ^ Joy Alcedo, Marina Ayzenzon, Tonia Von Ohlen, Markus Noll, Joan E. Hooper (1996 July 26) “The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal”, in Cell, volume 86, Cell Press, , pages 221–222