hyperfractionation
English
[edit]Etymology
[edit]International scientific vocabulary, from hyper- + fractionation = hyper- + fraction + -ation.
Pronunciation
[edit]- Rhymes: -eɪʃən
Noun
[edit]hyperfractionation (uncountable)
- (radiotherapy) An especially highly divided form of fractionation: the division of a total dose of radiation into many small fractions.
- 1983, H.D. Thames Jr, L.J. Peters, H.R. Withers, G.H. Fletcher, “Accelerated fractionation vs hyperfractionation: rationales for several treatments per day”, in International Journal of Radiation Oncology, Biology, Physics, volume 9, number 2, , →PMID, pages 127–138:
- Treatment with several doses per day offers the prospect of a significant therapeutic gain using readily available low LET beams. These regimens can be classified as either accelerated fractionation or hyperfractionation according to their rationales. With accelerated fractionation a conventional number of dose fractions is delivered in a significantly shortened overall treatment time in order to reduce the opportunity for tumor cell regeneration during treatment. With hyperfractionation, on the other hand, a large number of significantly reduced dose fractions is used to give a greater total dose in a conventional overall treatment time.