zalcitabine

English

Molecular structure of zalcitabine

Alternative forms

• dideoxycytidine, ddC, DDC

Etymology

From [Term?] +‎ -citabine (“cytarabine or azacytidine derivative”).

(This etymology is missing or incomplete. Please add to it, or discuss it at the Etymology scriptorium.)

Pronunciation

• (Received Pronunciation) IPA^(key): /zalˈsɪt.ə.biːn/
• (General American) IPA^(key): /zælˈsaɪ.təˌbin/, /zælˈsɪt.əˌbin/

Noun

zalcitabine (countable and uncountable, plural zalcitabines)

1. (pharmacology) A drug C₉H₁₃N₃O₃ which inhibits the replication of HIV and is formerly used in the treatment of AIDS, especially in combination with zidovudine. It is a synthetic analog of a pyrimidine nucleoside, acting as a reverse transcriptase inhibitor.
   • 1997 July 4, B. Autran et al., “Positive Effects of Combined Antiretroviral Therapy on CD4 T Cell Homeostasis and Function in Advanced HIV Disease”, in Science‎^[1], volume 277, number 5322, →DOI, pages 112–116:

     Patients received 600 mg/day of ritonavir (Abbott Laboratories) for 14 days, after which were added 600 mg/day of zidovudine (Retrovir, Glaxo-Wellcome) and 6 mg/day of zalcitabine (Hivid, Roche) with treatment maintenance for 12 months.

References

• “dideoxycytidine”, in Lexico, Dictionary.com; Oxford University Press, 2019–2022.
• “ddC”, in Merriam-Webster Online Dictionary, Springfield, Mass.: Merriam-Webster, 1996–present.

Italian

Noun

zalcitabine f

1. plural of zalcitabina