From Wiktionary, the free dictionary
Prepositional phrase
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with every fiber of one's being
- To the fullest extent possible.
- Synonyms: with every bone in one's body, with every ounce of one's being
1900, Joseph Conrad, Lord Jim, page xxxv. 244:The girl was righ - there was a sign, a call in them - something to which I responded with every fibre of my being.