vesamicol

English

Noun

vesamicol (uncountable)

1. (organic chemistry, medicine) The drug 2-(4-phenyl-1-piperidyl)cyclohexan-1-ol that inhibits acetylcholine
   • 2016 January 12, “In Vivo Differences between Two Optical Isomers of Radioiodinated o -iodo- trans -decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter”, in PLOS ONE‎^[1], →DOI:

     Because synapse loss and dysfunction occur before fibrillary tau tangles emerge in the tauopathy mouse AD model[20 ], VAChT may be used as a possible in vivo target for diagnoses of AD. It has been shown that vesamicol (2-(4-phenylpiperidino) cyclohexanol) binds to the ACh transporter on presynaptic acetylcholine storage vesicles and inhibits ACh uptake into the vesicle[21 ,22 ].

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