proteoform

English

Pronunciation

• (US) IPA^(key): /ˈpɹoʊtiːoʊˌfɔɹm/

Usage notes

The term includes all PTMs classified by the PSI-MOD ontology (which uses PSI-MS standardized names for protein modifications), except those classified as reagent derivatized residues (MOD:00848) or isotope labeled residues (MOD:00702).

Noun

proteoform (plural proteoforms)

1. A specific molecular form of a protein product arising from a specific gene.
2. Any of a group of related protein molecules arising from all combinatorial sources of variation giving rise to products arising from a single gene. These include products differing due to genetic variation, alternatively spliced RNA, transcripts, and post-translational modifications.

References

• https://web.archive.org/web/20130218005522/http://smith.chem.wisc.edu/research/proteoforms
• http://www.topdownproteomics.org
• Proteoform: a single term describing protein complexity. Nat Methods. 2013 Mar;10(3):186-7. doi: 10.1038/nmeth.2369.