pharmacomodulation
English
[edit]Etymology
[edit]From pharmaco- + modulation.
Noun
[edit]pharmacomodulation (countable and uncountable, plural pharmacomodulations)
- The modification of existing pharmaceuticals by replacing substituents etc
- 2015 August 14, “Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells”, in PLOS ONE[1], :
- Interestingly, the p-chloro- and p-trifluoromethyl-phenyl monophenols 10 and 11 retained activity (EC 50 = 4.0 ± 1.4 μM and 12.4 ± 6.9 μM, respectively) with an excellent selectivity versus proliferating TG1 GSCs, suggesting that pharmacomodulation is possible at this position.