mismethylate

English

Etymology

From mis- +‎ methylate.

Verb

mismethylate (third-person singular simple present mismethylates, present participle mismethylating, simple past and past participle mismethylated)

1. To methylate incorrectly.
   • 1994, A. Ian Scott, “The discovery of nature's pathway to vitamin B12. A 25 year Odyssey”, in Tetrahedron, volume 50, number 47:

     We did find that one of tbe Salmonella genes, cbiF, was capable of 'mismethylating' precorrin-3 at the 1 l-position, ie out of the natural order, to yield a tetramethyl pyrrocorphin

   • 2012, Karl Kadish, Kevin M. Smith, Roger Guilard, The Porphyrin Handbook, page 217:

     CysG is a homodimer with a subunit M_r of 50,000, which, in addition to catalyzing methylation at C-2 and C-7, can also mismethylate precorrin 2 at C-12 to afford a trimethylpyrrocorphin derailment product.

   • 2012, Jan Philip Wurm, Marco Griese, Ute Bahr, Martin Held, Alexander Heckel, Michael Karas, Jörg Soppa, Jens Wöhnert, “Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs”, in RNA:

     M. jannaschii Nep mismethylates T-arm resembling RNAs.

   • 2015, Robert A. Meyers, Synthetic Biology, page 412:

     Biosynthesis of Mismethylated Analogs of Cobalamin