keratorhexis
English
[edit]Etymology
[edit]Noun
[edit]keratorhexis (uncountable)
- (medicine) Rupture of the cornea.
- 1955, Charles I. Thomas, The cornea, page 249:
- This area then was flattened out near the sclera. It was not cone-shaped as in keratoconus, but cylindrical. In differential diagnosis Jauernig considered keratoconus, keratectasia and keratorhexis.
- 2004 October, Udo Vanhoefer, Mitra Tewes, Federico Rojo, Olaf Dirsch, Norbert Schleucher, Oliver Rosen, Joachim Tillner, Andreas Kovar, Ada H. Braun, Tanja Trarbach, Siegfried Seeber, Andreas Harstrick, José Baselga, “Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor”, in Journal of Clinical Oncology:
- One patient experienced conjunctivitis-induced keratorhexis after multiple administrations of EMD72000 at DL 3 (1,200 mg), which resolved within 1 week after symptomatic treatment.
- 2011 May, C. D. Weekes, P. LoRusso, V. Ramakrishnan, L. M. Shih, W. C. Darbonne, P. Hegde, Y. Xin, R. Yu, H. Xiang, R. K. Brachmann, A. Patnaik, “A phase Ib study for MNRP1685A (anti-NRP1) administered intravenously with bevacizumab with or without paclitaxel to patients with advanced solid tumors”, in Journal of Clinical Oncology, volume 29, number 15:
- Treatment-related grade 3-5 adverse events (AEs; cut-off date 11/23/10) included 1 sudden death, unknown etiology, at Day 7 in Arm A (36 mg/kg), neutropenia (n=4, all Arm B), proteinuria (n=3), thrombocytopenia (n=2), hypertension (n=2), and one each of fatigue, keratorhexis, and peripheral edema.