idiotype
English
[edit]Etymology
[edit]Pronunciation
[edit]- (US) IPA(key): /ˈɪ.diː.oʊ.taɪp/
- Hyphenation: i‧di‧o‧type
Audio (US): (file) Audio (Southern England): (file)
Noun
[edit]idiotype (plural idiotypes)
- (immunology) A characteristic shared by a group of immunoglobulin or T-cell receptor molecules, based on the antigen-binding specificity of their variable region; and thus, the resultant immunologic phenotype, which can often be specific to a person or to only a small percentage of people.
- 2000 March 31, Valerie Kouskoff et al., “T Cell-Independent Rescue of B Lymphocytes from Peripheral Immune Tolerance”, in Science[1], volume 287, number 5462, , pages 2501–2503:
- PD mice also lacked serum Ig of 3-83 specificity (3-83 idiotype).
- 1997 October 10, Fotini Papavasiliou et al., “V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses”, in Science[2], volume 278, number 5336, , pages 298–301:
- […] we stained µ i/ i/ B cells and controls with the Ac146, an antibody that recognizes the idiotype produced by the V B1-8 DJ H - V 3-83 J replacement combination (19 ).
