From Wiktionary, the free dictionary
fuckered up (comparative more fuckered up, superlative most fuckered up)
- (slang, vulgar) Messed up; out of order; broken.
2000 November 23, GetGoCar [username], “Re: Off Topic: Radiohead Kid A”, in alt.music.cheap-trick[1] (Usenet):why does it have to be MY generation that's all fuckered up?
2001 December 29, fil [username], “Re: Some Non-Ween Perma-Vines and/or Trades”, in alt.music.ween[2] (Usenet):My email is all fuckered up and I can't get the message through.
2004 March 19, Thrasher [username], “Everquest-can it be fixed?”, in comp.sys.ibm.pc.games.rpg[3] (Usenet):It got all fuckered up over the course of the last 3 or 4 expansions.
- (slang, vulgar) Stoned or intoxicated.
1999 December 30, Me [username], “Re: HELP!!!!! QUICK!!!!”, in alt.drugs.psychedelics[4] (Usenet):The best tip I can give you, however, is: Don't go around your parents all fuckered up on ANYTHING too many times, eventually they catch on.
2001 August 8, The Taliban Funster [username], “Re: 2 Ozzfest tickets for sale - NJ Aug 12”, in alt.rock-n-roll.metal.oldschool[5] (Usenet):Josh, so while we're talking, did I ever tell you about the time I saw Moby all fuckered up on Maker's Mark and shitty beer?
2001 December 6, Snarl67 [username], “Non alcholic beer (was Re: Mustangs Seat - Is this 'normal' ?)”, in rec.motorcycles.harley[6] (Usenet):This be ass bustin' work boys n' girls, long assed hours fer months on end, not the place to be all fuckered up on drugs er drink, nope.