citrullination
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English
[edit]
Etymology
[edit]From citrulline + -ation.
Noun
[edit]citrullination (plural citrullinations)
- (biochemistry) The posttranslational modification of the amino acid arginine in a protein into the amino acid citrulline.
- Synonym: deimination
- 2017, B. Amin, W. Voelter, “Human Deiminases”, in A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, editors, Progress in the Chemistry of Organic Natural Products, Volume 106, Springer, page 220:
- Naturally occurring/substituted amino acids, flanking targeted arginine, influence its susceptibility to citrullination by peptidylarginine deiminases.
- 2017, Alastair Wilkins, Progressive Multiple Sclerosis, 2nd edition, Springer, page 141:
- In MS citrullination is the most studied PTM[post-translational modification] from those listed in Table 6.1.
- 2019, Shuzheng Song, Yingyan Yu, Progression on Citrullination of Proteins in Gastrointestinal Cancers, Zhe-Sheng Chen, Jian-ye Zhang, Yunkai Zhang, Yan-yan Yan (editors), Targeted Cancer Therapies, From Small Molecules to Antibodies, Frontiers Media, page 162,
- The exact effect of citrullination of proteins on cancer should be studied further.
- Citrullination of proteins is not only detected in in vitro experiments, but also in human blood.