citrullination

English

Etymology

From citrulline +‎ -ation.

Noun

citrullination (plural citrullinations)

1. (biochemistry) The posttranslational modification of the amino acid arginine in a protein into the amino acid citrulline.

   Synonym: deimination

   • 2017, B. Amin, W. Voelter, “Human Deiminases”, in A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, editors, Progress in the Chemistry of Organic Natural Products, Volume 106, Springer, page 220:

     Naturally occurring/substituted amino acids, flanking targeted arginine, influence its susceptibility to citrullination by peptidylarginine deiminases.

   • 2017, Alastair Wilkins, Progressive Multiple Sclerosis, 2nd edition, Springer, page 141:

     In MS citrullination is the most studied PTM^{[post-translational modification]} from those listed in Table 6.1.

   • 2019, Shuzheng Song, Yingyan Yu, Progression on Citrullination of Proteins in Gastrointestinal Cancers, Zhe-Sheng Chen, Jian-ye Zhang, Yunkai Zhang, Yan-yan Yan (editors), Targeted Cancer Therapies, From Small Molecules to Antibodies, Frontiers Media, page 162,

     The exact effect of citrullination of proteins on cancer should be studied further.

     Citrullination of proteins is not only detected in in vitro experiments, but also in human blood.

Derived terms

• autocitrullination
• hypercitrullination