From Wiktionary, the free dictionary
So named from the bubbling and churning feeling that occurs in one's stomach and digestive tract.
bubble guts pl (normally plural, singular bubble gut)
- (informal, medicine, gastroenterology) A condition where one experiences bloating, cramping, and discomfort in the stomach or digestive tract due to gases caused by extreme hunger or explosive pre-diarrhea.
Every time I eat at that restaurant I wake up the next day with bubble guts.