Talk:Schmerzen
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The plural is usually wholy interchangeable with the singular and is the form usually used in compounds.
No, that is false;
Schmerztablette, Schmerzmittel, schmerzlindernd, Schmerzbehandlung, schmerzhaft, Schmerzvermeidung take the singular.
Singular and plural are distinct in their meanings:
„Ich habe einen Schmerz im Knie“ means: My knee is aching in some special angle and some special movement.
„Ich habe Schmerzen im Knie“ means: My knee is aching in many angles and more or less any movement.