MPTP

English

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Noun

MPTP (uncountable)

1. (neurotoxicology) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a byproduct of synthetic heroin, or MPPP, which causes parkinsonian symptoms in users; and a neurotoxin that degrades into MPP+ after crossing the blood-brain barrier, which causes a degradation of the dopaminergic neurons within the substantia nigra.

Quotations

• 2005 Dec 29 Petzinger, et al. Journal of Neuroscience Research [1]

  The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP provides an excellent opportunity to study repair and response to injury in the basal ganglia.