1657 — Richard Tomlinson (translator), A Medicinal Dispensatory: Containing the whole Body of Phyſick : Discovering the Natures, Properties, and Vertues of Vegetables, Minerals, & Animals: The manner of Compounding Medicaments, and the way to adminiſter them, page 143 (originally published in French as "Dispensatorivm Medicvm " by Jean de Renou, 1609)
But nothing doth ſo much dehort from a great quantity of any Medicament, as its effrenate, prepotent and malign quality; which as ſoon as it is educed into act, doth greviouſly diſturb Nature, and excites a troop of ſymptomes.
1818 — William Firth, Remarks on the Recent State Trials, and the Rise and Progress of Disaffection in the Country: To Which are Annexed Letters to and from the Bishop of Norwich, on the Tendency of His Public Opinions, page 47
[…] a satiety of personal revenge (that species of wild justice, as Lord Bacon terms it, which an infuriate multitude are fond, apt and daring in the effrenate indulgence of)[…]
1864 — The Edinburgh Review, Volume 119 (January-April), page 84
[…]after more than thirty years of effrenate persecution […]
